ウイルス
Online ISSN : 1884-3433
Print ISSN : 0042-6857
ISSN-L : 0042-6857
ウイルスの血球凝集反応の本態に関する研究
第2報 血球の自家呼吸とその血球の凝集価との関連性について
中川 洋新宮 正久
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ジャーナル フリー

1958 年 8 巻 2 号 p. 100-110

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Many interesting problems still remain to be studied in the field of viral hemagglutnation. The present authores have taken particular interest in the findings that viruses have specific affinity to the componen's of the erythrocytes. The biochemical studies of the metabolic process of erythrocytes treated with virus are to be made in parallel with electrostatical studies, and so the mechanism of the viral hemagglutination might be expected to be easily understood.
The authores have made biochemical and electrostatical studies on viral hemagglutination.
The present paper deals with the results of the manometrical experiment which have been undertaken on oxidative respiration of erythrocytes treated with virus. And it has been observed that the existence of a certain mathematical relationship between the endogenous oxidative respiration of erythrocytes and its hemagglutination titer.
In fact, if, changing various conditions of hemagglutination (kinds of reaction medium; addition of serum or glucose to medium) and using various erythrocytes (those treated with trypsin, tannic acid, virus, or RDE), measurement is to be conducted on the influence of the endogenous oxidative respiration of erythrocytes on the hemagglutination titer, one may notice that hemagglutination titer decreases with the increase of the endogenous oxidative respiration, on the other hand, hemagglutination titer increases with the decrease of the endogenous oxidative respiration of erythrocytes.
All these findings would indicate that there exists a common component, between the substrate of endogenous oxidative respiration enzyme end the important part of receptor of erythrocytes.

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