Overdose Ingestion of Pimobendan in a Dog

抄録

A 15-year-old castrated male Shih Tzu (weight 8.5 kg) with myxomatous mitral valve disease ingested 8.24 mg/kg of pimobendan (approximately 33 times the recommended dose). On presentation, tachycardia and systemic hypertension were observed. Echocardiography revealed systolic anterior motion of the mitral valve (SAM) and increased fractional shortening. Electrocardiography revealed an increased T wave to R wave amplitude ratio (T/R). SAM disappeared 12 hr after hospitalization. T/R normalized after 24 hr, although the mechanism of the increase in this ratio and its clinical significance remain unclear. Systemic hypertension disappeared 36 hr after hospitalization. These findings suggest that it is necessary to monitor T/R, SAM, and systemic hypertension in dogs who have ingested a large amount of pimobendan.