抄録
Myocardium consists of cardiac myocytes, fibroblastic cells, and vascular cells, mainly. However, the clinical significance of cell-cell interaction between these cells is controversial. Cardiac myocytes contain fibroblast growth factors (FGF-1,2) and endothelin1(ET-1). On the other hand, cardiac fibroblastic cells also synthesize ET-1. The synthesis of FGFs and ET-1 in the myocardium are reported to be stimulated in the ischemic lesions. FGFs stimulate the growth of vascular cells and fibroblastic cells, therefore, FGFs may contribute to the formation of vascularization or fibrosis. Because ET-1 stimulates cardiac contraction, ET-1 may contribute the maintenance of contractile ability in the ischemic myocardium. Pathophysiological roles of FGFs and ET-1 in heart are discussed at the point of view of cell-cell interaction between cardiac myocytes and cardiac fibroblastic cells.
