農村女性における血清中のセレンとコレステ口ールの濃度関係の追跡研究

抄録

Serum samples were collected from 167 Japanese rural women (aged 35-81 years) in 1990 and from the same subjects in 1992. Atherogenic index [=(total cholesterol - HDL-cholesterol) /HDL-cholesterol] was a significant increasing factor of the serum selenium (Se) concentration in 1990 for women aged above 60 years by multiple regression analyses, which was consistent with our preliminary findings for coastal inhabitants of Fukui Pref. in 1986. Furthermore, the change in atherogenic cholesterol concentrations (total cholesterol - HDL-cholesterol) between the sampling years was a significant increasing factor of the change in serum Se concentrations for all subjects. Thus, our results suggest that serum Se concentration can increase as atherogenic cholesterol concentration increases for Japanese women and such a positive relationship may reflect some role of serum selenium in protecting atherogenic lipoproteins from oxidation.