プロシーディング
モルモット心室筋の収縮力に対するかき肉エキスの影響
1997 年 14 巻 p. 123-127
詳細
1997 年 14 巻 p. 123-127
The effect of oyster extract (s) (OE) on the electrically-driven (force of) contraction in guinea-pig papillary muscles was studied. OE (1mg/ml) produced a transient negative inotropic effect followed by continuous positive inotropic effect (PIE). Increases in PIE was 6%, 20% and 33% at the 0.1, 0.3 and 1mg/ml of OE concentrations, respectively. Pretreatment of catecholamine β1 antagonist, metoprolol (3×10-7M), and catecholamine α1 antagonist, prazosin (10-7M), did not inhibit the PIE of OE (1mg/ml). However, calcium channel antagonist, nicardipine (10-7M), partially inhibit the PIE of OE. Diphenhydramine (10-5M), histamine (H1) antagonist, markedly inhibited the PIE of OE, whereas cimetidine (10-4M) , histamine (H2) antagonist, had no effect.
These findings suggest that the PIE of OE was mediated mainly by the stimulation of histamine (H1) receptors and partially by activation of L-type calcium channels.
