プロシーディング
The Induction and Control of Oxidation Damage caused by arsenic and UV Radiation exposure to Euglena gracilis SMZ
2004 年 21 巻 p. 1-5
詳細
2004 年 21 巻 p. 1-5
Arsenic (As) is a ubiquitous element in the environment. Chronic As poisoning from natural and anthropogenic sources has become one of the most significant environmental health problems affecting over 100 million people worldwide1). As leads human carcinogen. It causes increased cancer risk of skin, lung, bladder and other internal organ systems2). There had been many failed attempts, as review by Wang et al.3), to demonstrate As carcinogenicity in- vivo animal systems until recent years. Chronic exposure of sodium arsenate caused multiple tumours in C57Bl/6J mice4). Waalkes et al.5) were able to demonstrate transplacental carcinogenic effects of arsenite dosed to the pregnant C3H mice resulting in a higher incidence of cancers in the offspring at their late stage of life.
Solar ultraviolet radiation (UVR) is responsible for the induction of more than 90% of non-melanoma skin cancers11). This is of particular concern in view of the consequences of stratospheric ozone depletion. It has been estimated that every 1% depletion of ozone concentration results in a 2% increase in the amount of UVR the earth6).
It has been demonstrated that As enhanced the number of skin cancers in mice induced by UV exposure7). Since people who live in As-endemic areas are also exposing to UV radiation. The significance of the combined effect of arsenic and UV radiation need further investigation.
Euglena gracilis SMZ strain.has been shown as a useful model for the study of oxidative damage induced by a number of metals including mercury, lead and cadmium8,9), In this study, we investigate the oxidative effect of arsenic and/or UVB exposure in E. gracilus SMZ strain.
