プロシーディング
工タノール誘導ラット肝ミク口ゾームによる基質酸化反応と活性酸素種との相関
2004 年 21 巻 p. 7-10
詳細
2004 年 21 巻 p. 7-10
Cytochrome P450 is a group of enzymes that are responsible for the biotransformation of numerous endogenous and exogenous compounds. However, the precise process of dioxygen activation involved in P450-dependent substrate oxygenations has not been established. Previously, we reported that singlet oxygen (1O2) played an important role in microsomal P450-dependent oxygenation. In order to confirm the 1O2 involvement, we investigated further the relationship between the formation of reactive oxygen species (ROS) and a substrate oxygenation in the ethanol-induced rat liver microsomal P450.
