Antioxidant activity of eugenol compounds

抄録

Antioxidant action of eugenol compounds was analyzed in relation to the role of transition metal. Eugenol and isoeugenol inhibited iron-mediated lipid peroxidation, and autooxidation of Fe²⁺ ion. Inhibitory effects of isoeugenol on lipid peroxidation and iron oxidation were more potent than those of eugenol. Eugenol and isoeugenol protected low density lipoprotein (LDL) from copper-dependent oxidation, and showed a potent copper-reducing activity to the same extent. Both compounds effectively scavenged a stable radical, 1,1’-diphenyl-2-picrylhydrazyl(DPPH). Antioxidant properties of eugenol compounds can be explained by forming complexes with reduced metals, and the potent preventive effect of isoeugenol on lipid peroxidation may be related to the decreased formation of perferryl ion or the iron-oxygen chelate complex as the initiating factor of lipid peroxidation by keeping iron at a reduced state.