Excessive accumulation of calcium and movement of parathyroid hormone (PTH) in the olfactory system by zinc deficiency

抄録

Zinc deficiency induced an excessive accumulation of calcium in the olfactory system. This calcium localization was parallel with the degree of symptom manifestation of zinc deficiency. Therefore, to investigate the mechanism on the calcium localization in the olfactory system, the movement of parathyroid hormone (PTH), cAMP and inositol triphosphate (IP₃) which play a part in olfactory signal transduction and Ca-homeostasis were analyzed in the olfactory epithelium, olfactory bulb and cerebrospinal fluid of zinc deficient rats.

Results were as follows; 1) Calcium showed a remarkable decrease in the cerebrospinal fluid and a remarkable increase in the olfactory tissues. 2) Magnesium also showed a decrease in the cerebrospinal fluid and increases in the olfactory tissues, although the movements were much lower than those of calcium. 3) PTH showed significant increases in both the cerebrospinal fluid and the olfactory tissues at the progress period. However, significant decreases in the olfactory tissues and a remarkable increase in the cerebrospinal fluid were seen at the perfection period of zinc-deficiency. 4) cAMP revealed excessive increases in the olfactory epithelium and olfactory bulb at the progress period of zinc deficiency. On the other hand, a little decreases in the olfactory epithelium and olfactory bulb were seen at the perfection period of zinc-deficiency. 5) Regarding IP₃, as well as cAMP, excessive increases in the olfactory epithelium and olfactory bulb were seen at the progress period of zinc deficiency. At the perfection period of zinc-deficiency, however, significant decreases were seen in the olfactory tissues.