各種金属ク口リンキレートの光力学作用について

抄録

The mechanism of photodynamic action and application for tumor diagonosis of pheophorbide (Pheo) derivatives have been investigated in our laboratory. Chlorin ( Chl), which has a hydrophilic property, is more suitable for photodynamic therapy than pheophorbide, because accumulation of Chl in normal tissues was very low. And we probed that ⁴⁸V-labeled Chl is useful as a tumor diagnostic agent for positron CT.

In this experiment, the cell-killing effect and hemolysis of new metal Chl chelates (Fe-Chl, Co-Chi, Ni-Chl, Zn-Chl) were studied. The cell-killing effect and hemolysis of metal Chl chelates under irradiation is much lower than free Chi. Fe-Chi have hemolysis action without irradiation. We suggested that the mechanism of hemolysis by Fe-Chl is the oxidation of substrates of cell membrane.