The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Regular Paper
LACK OF CARCINOGENIC RISK IN THE PROSTATE WITH TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A IN RATS
Toshio ICHIHARAHiroko YOSHINONorio IMAITomoko TSUTSUMIMayumi KAWABESeiko TAMANOShingo INAGUMAShugo SUZUKITomoyuki SHIRAI
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2003 Volume 28 Issue 3 Pages 165-171

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Abstract

The current study was designed to examine the modulating effects of bisphenol A (BPA) on prostate cancer risk in male offspring exposed transplacentally and lactationally. BPA was administered to F344 female rats by gavage at 0, 0.05, 7.5, 30, 120 mg/kg/day during pregnancy and lactation periods. When F1 males reached 5 weeks old, they were given 10 subcutaneous injections of 3,2'-dimethyl-4-aminobiphenyl (DMAB) or corn oil vehicle and rats were then sacrificed under ether anesthesia at week 60. There were no observable effects on the accessory sex organ weights of male offspring. Transplacental and lactational exposure to BPA did not affect the incidences of preneoplastic and neoplastic lesions in the accessory sex organs (prostate and seminal vesicle) of F1 rats and did not induce any proliferating lesions without DMAB. Our data suggest that maternal exposure to BPA during the period of pregnancy and lactation does not affect the risk of prostate carcinogenesis in male offspring.

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© 2003 The Japanese Society of Toxicology
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