The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Toxicogenomics/proteomics Report
Microarray analysis of the liver in metallothionein-III null mice treated with cadmium
Akiko HondaHiroaki KomuroHisamitsu NagaseIsao HozumiTakashi InuzukaHideaki HaraYasuyuki FujiwaraMasahiko Satoh
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Keywords: MT-III, Cd, DNA microarray, Liver
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2010 Volume 35 Issue 2 Pages 271-273

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Abstract

In order to elucidate the effect of metallothionein (MT)-III on hepatic gene expression altered by cadmium (Cd), we examined gene expression patterns in the liver of MT-III null mice and wild-type mice after Cd injection using a DNA microarray containing 35,852 genes. In a comparison between Cd-injected MT-III null mice and Cd-injected wild-type mice, 9 genes were found to be up-regulated and 28 genes—including serum amyloid A1 (SAA-1) and SAA-2—were down-regulated.

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© 2010 The Japanese Society of Toxicology
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