The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
β-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma
Emma Muñoz-SaezEstefanía de MunckRosa M. ArahuetesM. Teresa SolasAna M. MartínezBegoña G. Miguel
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2013 Volume 38 Issue 3 Pages 425-430

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Abstract

β-N-methylamino-L-alanine (L-BMAA) is a neurotoxic amino acid produced by most cyanobacteria, which are extensively distributed in different environments all over the world. L-BMAA has been linked to a variety of neurodegenerative diseases. This work aims to analyze the toxicological action of L-BMAA related to alterations observed in different neurodegenerative illness as Alzheimer disease and amyotrophic lateral sclerosis. Our results demonstrate that neuroblastoma cells treated with L-BMAA show an increase in glycogen synthase kinase 3 β (GSk3β) and induce accumulation of TAR DNA-binding protein 43 (TDP-43) truncated forms (C-terminal fragments), phosphorylated  and high molecular weight forms of TDP-43, that appears frequently in some neurodegenerative diseases.

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© 2013 The Japanese Society of Toxicology
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