The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
Letter
Cannabidiol-2’,6’-dimethyl ether stimulates body weight gain in apolipoprotein E-deficient BALB/c. KOR/Stm Slc-Apoeshl mice
Shuso TakedaRena HirotaSari TeradairaMasumi Takeda-ImotoKazuhito WatanabeAkihisa TodaHironori Aramaki
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2015 Volume 40 Issue 6 Pages 739-743

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Abstract

The biological activities of cannabidiol (CBD), a major non-psychotropic constituent of the fiber-type cannabis plant, have been examined in detail (e.g., CBD modulation of body weight in mice and rats). However, few studies have investigated the biological activities of cannabidiol-2’,6’-dimethyl ether (CBDD), a dimethyl ether derivative of the parent CBD. We herein focused on the effects of CBDD on body weight changes in mice, and demonstrated that it stimulated body weight gain in apolipoprotein E (ApoE)-deficient BALB/c. KOR/Stm Slc-Apoeshl mice, especially between 10 and 20 weeks of age.

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© 2015 The Japanese Society of Toxicology
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