The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons
Nozomi AsaokaHiroyuki KawaiNaoya NishitaniHaruko KinoshitaNorihiro ShibuiKazuki NagayasuHisashi ShirakawaShuji Kaneko
Author information
JOURNALS FREE ACCESS
Supplementary material

2016 Volume 41 Issue 6 Pages 813-816

Details
Abstract

N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-3-methyl-D-valine methyl ester (5F-ADB) is one of the most potent synthetic cannabinoids and elicits severe psychotic symptoms in humans, sometimes causing death. To investigate the neuronal mechanisms underlying its toxicity, we examined the effects of 5F-ADB on midbrain dopaminergic and serotonergic systems, which modulate various basic brain functions such as those in reward-related behavior. 5F-ADB-induced changes in spontaneous firing activity of dopaminergic and serotonergic neurons were recorded by ex vivo electrophysiological techniques. In dopaminergic neurons, 5F-ADB (1 μM) significantly increased the spontaneous firing rate, while 5F-ADB failed to activate dopaminergic neurons in the presence of the CB1 antagonist AM251 (1 μM). However, the same concentration of 5F-ADB did not affect serotonergic-neuron activity. These results suggest that 5F-ADB activates local CB1 receptors and potentiates midbrain dopaminergic systems with no direct effects on midbrain serotonergic systems.

Information related to the author
© 2016 The Japanese Society of Toxicology
Previous article
feedback
Top