2023 年 49 巻 1 号 p. 37-47
To ensure safety in chemical plants handling a wide variety of liquid and gaseous hazardous substances, it is necessary to carry out highly accurate risk assessments and take appropriate measures. In this study, a risk assessment method was developed for the problem of the leakage of liquid hazardous substances. The risk assessment of toxic liquid leaks must consider the exposure of workers to the liquid and toxic gases produced by vaporization. The absorption and subsequent metabolism of hazardous substances in the body via multiple pathways after exposure to liquids and gases was calculated using a pharmacokinetic model. Estimation of exposure concentrations of toxic gases volatilized from leaked liquids was reproduced by computational fluid dynamics simulation. In this study, ethanol was selected as the hazardous substance and the risk of hazardous liquid leakage was assessed. The results of the analysis, which considered liquid and gas exposure under the conditions of the assumed scenario, showed that the maximum blood concentration of ethanol was 1640 µmol/L, which is sufficiently low compared to the concentration of 10,900 µmol/L at which acute toxic effects become apparent. These results suggest that work can be carried out safely under the conditions of the assumed scenario. The risk assessment methodology for liquid spills in this study confirms that risk assessment is possible under multiple scenarios, including individual differences, activity conditions, and the use of protective equipment.
