EFFECT OF D-GALACTOSAMINE ON BLOOD CLEARANCE OF <99m>Tc-PHYTATE IN RATS
Keywords:
reticuloendothelial system
1989 Volume 14 Issue 3 Pages 205-213
Details
1989 Volume 14 Issue 3 Pages 205-213
The effect of D-galactosamine (GalN) on the blood clearance of <99m>Tc-phytate (<99m>Tc-P) in rats was examined, and the blood clearance test of <99m>Tc-P was compared with the cases of serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in rats increased dosedependantly after GalN administration. The disappearance rate of <99m>Tc-P from blood decreased with the increase in dose of GalN and with the passage of time after the GalN administration. Changes of the blood clearance of <99m>Tc-P after GalN treatment in rats may be influenced by the disorder in the hepatocytes and the alteration of the liver reticuloendothelial system phagocytic function. The blood clearance test of <99m>Tc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by GalN equally to or higher than the serum transaminase and bilirubin test.
