MUTAGENICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (1) : REVERSE MUTATION ASSAYS IN S.TYPHIMURIUM AND E.COLI TESTER STRAINS

Atsushi HAKURA; Fumio SAGAMI; Piero TIRONE; Alberto MORISETTI; Simona BUSSI; Franca FASSIO

doi:10.2131/jts.24.SupplementI_89

Atsushi HAKURA, Fumio SAGAMI, Piero TIRONE, Alberto MORISETTI, Simona BUSSI, Franca FASSIO

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Keywords: Escherichia coli

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1999 Volume 24 Issue SupplementI Pages 89-94

DOI https://doi.org/10.2131/jts.24.SupplementI_89

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Abstract

The ability of gadobenate dimeglumine formulation (E7155) to cause gene mutations was assessed in five strains of Salmonella typhimurium (TA100, TA1535, TA98, TA1538, and TA1537) and a strain of Escherichia coli (CM891; WP2, uvrA-, pKM101) using the Ames test (agar plate assay). The results suggest that E7155 is non-mutagenic towards these bacterial tester strains.

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