Clinical Application of Sulfadimethoxin to Diarrhea in Swine

Abstract

Sulfadimethoxin is regarded in human medicine as a long-acting sulfonamide. It is characteristic of this drug that a high and prolonged blood level is maintained after medication of a low dosage of the drug.
Veterinary medicine to administera high dosage of sulfonamide. In this examination, however, some effect was obtained from smaller dosages than those conventionally used for swine.
The first method employed consisted of intramuscular injection of 20 mg per kg of body weight, which was followed by that of 10 mg/kg 8 hours later. In this case, blood levels of 3. 5-3. 9 mg% were maintained in swine 24 hours after the initial administration.
In another method, swine were given a single dose of 40 mg/kg and showed blood levels of 2.7-3.5 mg% 24 hours after administration. In these trials, 10% solution of sulfadimethoxin in sterilized water was used.
These methods gave good results in experimental treatment of bacterial diarrhea of swine in 91 cases.
No marked side-effect was seen in any case.