Abstract
Bayer L 13/59 (Neguvon), an organic phosphate with low toxicity, has frequently been used for the treatment of canine demodecosis in recent years. There are, however, few studies on the effect of this compound on the cholinesterase activity of canine serum and tissues. The present investigation clarified that treatment with dose of 50 mg/kg of the compound induced a reduction (40-50%) in cholinesterase activity, a rapid return to normal, and no toxic manifestations. The method widely adopted of administering three doses on the 1st, 3rd, and 9th day of 50 mg/kg each was found to be of the same effect as the repetition of the onedose method mentioned above. This method brought about no cumulative toxicity and was proved to be safe for the purpose of treatment.
