1989 Volume 42 Issue 2 Pages 120-123
One 20-day-old, male piglet died showing an icteric tinge on a Kagoshima Prefecture swinery. By histopathological examinations, basophilic intranuclear inclusions were found in megalocytes, which appeared in the liver, spleen, lungs, and mesenteric lymph nodes. The inclusions demonstrated a positive Feulgen reaction. Electron microscopy revealed numerous herpes virus-like particles in intranuclear inclusions. Specific fluoresecnce was demonstrated in relation to intranuclear inclusions by the indirect fluorescent antibody test using anti-porcine cytomegalovirus (PCMV) swine sreum. Based on these results, the present cases was diagnosed as a disease caused by PCMV. A serological survey performed on the swinery indicated 66.7% of the pigs were positive for antibody against PCMV. However, the dam of the diseased piglet was negative for antibody to PCMV. It was presumed, therefore, that the present case may have become infected with PCMV sometime between 5 and 10 days after its birth.
