Abstract
After intratracheal inoculation into 6-week-old guinea-pigs with various doses ofActinobacilluspleuropneumoniaeserotype 1, strain HA-337, most animals showed depression, anorexia and dyspnea within one week, and 2 of 3 animals infected with 107CFU died on day 6 postinoculation. The gross lesions were located mainly in the apical and cardiac lobes of the lungs, and histology revealed purulent bronchopnemonia but no fibrinous pleurisy in all infected cases. The organisms were isolated from all animals infected with 107CFU, and one each infected with 105and 103.
