1999 Volume 52 Issue 5 Pages 315-318
An 8-year-old spayed female mixed-breed dog showed anorexia and severe anemia and the condition was improved after blood transfusion. On day 35 of illness, however, the patient showing anorexia and vomitting had pain in the hindquarter, severe anemia and elevated levels of serum protein and calcium. Two monoclonal peaks of gamma-globulin fraction were shown by electrophoresis, and the M-component was immunoelectrophoretically confirmed to be IgA. Splenomegaly and “punch-out” osteolysis were detected by radiography. Peroxidase-negative and IgA-positive mononuclear cells were predominant on bone marrow biopsy and the case was diagnosed as multiple IgA myeloma (stage III), and melpharan and predonisolone treating was started. On day 84 of illness the patient died of sudden dispnea and vomitting.
