Abstract
Ligation of the thoracic duct was attempted for a female Shetland sheepdog (four years old) suffering from chylothorax. Radiography revealed a small amount of pleural effusion 37 days later. Although medical therapy was attempted to alleviate the condition, the effusion increased. Consequently at 92 days, to promote pleural adhesion, we administered OK-432. The initial dose was 1KE; a total of 8KE was injected into the thorax on four occasions over a period of 46 days. The dog showed no significant adverse effects, and the effusion decreased. Currently, after 18 months, the dog is asyptomatic, in good health, and free of signs of pleural effusion.