Amplification of the c-yes Oncogene in Canine Mammary Tumors

Anudep RUNGSIPIPAT; Susumu TATEYAMA; Ryoji YAMAGUCHI; Kazuyuki UCHIDA; Yuichi MURAKAMI; Noriaki MIYOSHI; Toshiharu HAYASHI

doi:10.1292/jvms.61.185

Anudep RUNGSIPIPAT, Susumu TATEYAMA, Ryoji YAMAGUCHI, Kazuyuki UCHIDA, Yuichi MURAKAMI, Noriaki MIYOSHI, Toshiharu HAYASHI

Author information

Anudep RUNGSIPIPAT
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki, 889-2192, Japan
Susumu TATEYAMA
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki, 889-2192, Japan
Ryoji YAMAGUCHI
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki, 889-2192, Japan
Kazuyuki UCHIDA
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki, 889-2192, Japan
Yuichi MURAKAMI
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki, 889-2192, Japan
Noriaki MIYOSHI
Kagoshima University, 1-21-24 Korimoto, Kagoshima, 890-0065, Japan
Toshiharu HAYASHI
Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan

Keywords: c-yes, canine, mammary tumor

JOURNAL FREE ACCESS

1999 Volume 61 Issue 2 Pages 185-189

DOI https://doi.org/10.1292/jvms.61.185

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Abstract

Genomic DNAs of 14 mammary tumors were analyzed by Southern blot hybridization using a human c-yes-1 oncogene probe. The amplification was successful in half of the cases (7 adenocarcinomas). The degree of amplification was approximately 4-fold, and a high proportion was seen in malignant tumors. In addition, DNA polymorphism was detected in two adenocarcinomas.

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