Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Replacement of Internal Protein Genes, with the Exception of the Matrix, in Equine 1 Viruses by Equine 2 Influenza Virus Genes during Evolution in Nature
Toshihiro ItoYoshihiro KawaokaMaki OhiraHiroki TakakuwaJiro YasudaHiroshi KidaKoichi Otsuki
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1999 Volume 61 Issue 8 Pages 987-989


To establish the evolutionary association between the equine 1 H7 HA and M genes, phylogenetic analyses of the six internal gene segments of equine 1 influenza viruses (H7N7 subtype) were performed using partial nucleotide sequences. The results demonstrated that five internal genes (PB1, PB2, PA, NP and NS) of equine 1 viruses isolated after 1964 were replaced by those of equine 2 H3N8 viruses. However, the M gene was maintained during the evolution of these equine 1 viruses. These findings suggest a functional association between equine H7 HA and M gene products, most likely M2 protein.

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