Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Relationship between Serum TNF Activity and Insulin Resistance in Dairy Cows Affected with Naturally Occurring Fatty Liver
Hiromichi OHTSUKAMasateru KOIWAAtsushi HATSUGAYAKatsunori KUDOFumio HOSHINoboru ITOHHiroshi YOKOTAHiroyuki OKADASei-ichi KAWAMURA
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2001 Volume 63 Issue 9 Pages 1021-1025


To clarify the relationship between tumor necrosis factor (TNF) and insulin resistance in dairy cows affected with fatty liver, naturally occurring cases were investigated. The affected cows were classified into following three groups according to histopathologic findings of the liver: mild fat droplet deposition (group 1; n=11), severe fat droplet deposition (group 2; n=10), and cloudy swelling (group 3; n=8). Serum TNF activities in Group 2 (8.67 ± 2.16 U/ml) and Group 3 (11.65 ± 1.92 U/ml) were significantly higher than that in Group 1 (3.57 ± 0.81 U/ml) (p<0.05). The insulin-tolerance tests showed that the insulin-stimulated glucose disposal rates (GDR) in Group 2 (27.6 ± 7.8%) and Group 3 (15.8 ± 9.1%) were significantly lower than that in Group 1 (41.7 ± 9.8%). There was a significant negative correlation between serum TNF activity and GDR in affected cows (r=-0.56, p<0.01). These results indicate that serum TNF activity is correlated with insulin resistance in cows with fatty liver.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
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