Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
NOTE
Improvement of Anemia Associated with Chronic Renal Failure by Recombinant Human Erythropoietin Treatment in ICR-Derived Glomerulonephritis (ICGN) Mice
Misuzu YAMAGUCHI-YAMADANoboru MANABEYasufumi GOTOSayuri ANANKeiko MIYAMOTOYouhei MIYAMOTOMasaya NAGAOYoshie YAMAMOTOAtsuo OGURA
Author information
JOURNALS FREE ACCESS

2004 Volume 66 Issue 7 Pages 883-886

Details
Abstract

The ICR-derived glomerulonephritis (ICGN) mouse, a novel inbred mouse strain with a hereditary nephrotic syndrome, develops severe anemia associated with chronic renal failure. To reveal the pathogenic mechanism of anemia in ICGN mice, we subcutaneously administered recombinant human erythropoietin (rhEPO; 5 IU/mouse/day) or saline for 5 days to ICGN mice. In terminal-stage ICGN mice with severe anemia, rhEPO significantly increased hematocrit (Ht), red blood cells (RBC) and hemoglobin levels. Endogenous EPO levels in peripheral blood were reduced by rhEPO injection. No histopathological changes in bone marrow and kidneys were induced by rhEPO injection. Insufficiency of EPO may cause anemia in ICGN mice.

Information related to the author

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Previous article Next article
feedback
Top