Phenotypic Analysis of Hepatic T Lymphocytes in a Dog with Chronic Hepatitis

Manabu SAKAI; Isao OTANI; Kumiko ISHIGAKI; Kazuya EDAMURA; Tomoko TAKAHASHI; Hiroshi KOIE; Yoshiki YAMAYA; Toshihiro WATARI; Hisashi SHIBUYA; Tsuneo SATO; Kiichi KANAYAMA; Mikihiko TOKURIKI; Atsuhiko HASEGAWA

doi:10.1292/jvms.68.1219

NOTE

Phenotypic Analysis of Hepatic T Lymphocytes in a Dog with Chronic Hepatitis

Manabu SAKAI, Isao OTANI, Kumiko ISHIGAKI, Kazuya EDAMURA, Tomoko TAKAHASHI, Hiroshi KOIE, Yoshiki YAMAYA, Toshihiro WATARI, Hisashi SHIBUYA, Tsuneo SATO, Kiichi KANAYAMA, Mikihiko TOKURIKI, Atsuhiko HASEGAWA

Author information

Manabu SAKAI
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Isao OTANI
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Kumiko ISHIGAKI
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Kazuya EDAMURA
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Tomoko TAKAHASHI
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Hiroshi KOIE
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Yoshiki YAMAYA
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Toshihiro WATARI
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Hisashi SHIBUYA
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Tsuneo SATO
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Kiichi KANAYAMA
Laboratory of Veterinary Physiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Mikihiko TOKURIKI
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Atsuhiko HASEGAWA
Laboratory of Pathobiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

Keywords: canine chronic hepatitis, lymphocyte, phenotype

JOURNAL FREE ACCESS

2006 Volume 68 Issue 11 Pages 1219-1221

DOI https://doi.org/10.1292/jvms.68.1219

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Abstract

We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33 ± 0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.

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