Measurement of Feline Serum Interleukin-5 Level

Abstract

A bioassay was developed to measure feline interleukin-5 (IL-5). Human IL-5 receptor α chain transfected murine Ba/F3 cells (Ba/F3-IL-5R) showed feline IL-5-dependent proliferation in a dose-dependent manner. IL-5 levels in serum samples from 54 cats with suspected allergic dermatitis and from 11 control cats could be successfully measured using Ba/F3-IL-5R cells. The number of eosinophils in peripheral blood was not correlated with serum IL-5 level.