Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
Physiology
Ubiquitin C-Terminal Hydrolase L1 Deficiency Decreases Bone Mineralization
Sehwan SHIMYoung-Bae KWONYasuhiro YOSHIKAWAJungkee KWON
Author information
JOURNALS FREE ACCESS

Volume 70 (2008) Issue 6 Pages 649-651

Details
Download PDF (330K) Contact us
Abstract

Ubiquitin C-terminal hydrolase L1 is a component of the ubiquitin proteasome system, which evidences unique biological activities. In this study, we report the pattern of UCH-L1 expression, and show that it regulates bone mineralization in osteogenesis. UCH-L1 was expressed in osteoblasts, osteoclasts, and hematopoietic precursor cells of bone marrow in the metaphysis and diaphysis of the femora. To further assess the involvement of UCH-L1 in the regulation of bone mineralization, we evaluated the bone mineral density (BMD) rate of gad mice, using the Latheta computed tomography system. Male gad mice evidenced a significantly decreased BMD rate in the metaphysis and diaphysis of the femora. These findings of decreased BMD rate in the bones of gad mice may suggest that UCH-L1 function regulates bone mineralization during osteogenesis.

Information related to the author
Previous article Next article
feedback
Top