Gene Expression of Adrenomedullin in Canine Normal Tissues and Diseased Hearts

Nobuyuki KANNO; Kazushi ASANO; Kenji TESHIMA; Kenji KUTARA; Mamiko SEKI; Kazuya EDAMURA; Rui KANO; Atsuhiko HASEGAWA; Shigeo TANAKA

doi:10.1292/jvms.71.789

Internal Medicine

Gene Expression of Adrenomedullin in Canine Normal Tissues and Diseased Hearts

Nobuyuki KANNO, Kazushi ASANO, Kenji TESHIMA, Kenji KUTARA, Mamiko SEKI, Kazuya EDAMURA, Rui KANO, Atsuhiko HASEGAWA, Shigeo TANAKA

Author information

Nobuyuki KANNO
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Kazushi ASANO
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Kenji TESHIMA
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Kenji KUTARA
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Mamiko SEKI
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Kazuya EDAMURA
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Rui KANO
Laboratory of Veterinary Pathobiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Atsuhiko HASEGAWA
Laboratory of Veterinary Pathobiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
Shigeo TANAKA
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

Keywords: adrenomedullin, canine, congestive heart failure

JOURNAL FREE ACCESS

2009 Volume 71 Issue 6 Pages 789-792

DOI https://doi.org/10.1292/jvms.71.789

Details

Abstract

The purposes of this study were to determine the tissue distribution of canine adrenomedullin (AM) and to determine whether increased canine AM mRNA expression is associated with congestive heart failure (CHF) due to mitral regurgitation (MR). Canine AM mRNA expression was detectable in various normal tissues, including cardiovascular tissues. In addition, the AM mRNA expression in the left atrium of dogs with MR was significantly higher than that in normal subjects. In conclusion, AM is a potential neurohumoral factor in dogs with CHF due to MR.

Corresponding author

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