Abstract
A case of peripheral acanthomatous ameloblasoma of the angulus orisa in a 6-year-old female rabbit was described. The tumor composed of confluent follicles of stellate reticulum with peripheral cuboidal to reverse polarized columnar cells with nuclear palisading in the submucosa of the angulus orisa. The follicular cell elements stained positive for pan-cytokeratin. Additionally, there were multifocal keratinizing foci of the stellate reticulum with some mineralization. Calcified product such as enamel or dentin was not formed. Acanthomatous ameloblasoma in the submucosa of the angulus orisa has not been described and it may develop from an ectopic rest of odontogenic tissue. After excision, neither local recurrence nor metastasis has been observed.