2011 Volume 73 Issue 6 Pages 821-826
The purpose of this study was to evaluate whether Nε-hexanoyl lysine (Nε-HEL) and acrolein reflect the severity of cisplatin-induced nephrotoxicity. Immunoexpression of Nε-HEL and acrolein in kidneys and their urinary concentration were examined up to day 4 post-cisplatin injection in rats. Cisplatin-induced tubular injury was observed histopathologically on days 2-4 after injection and became more severe time-dependently. On days 2-4, Nε-HEL and acrolein were immunostained in the cytoplasm of damaged tubular cells. Their immunostaining intensity and urinary levels increased as tubular injury became more severe. These results suggest that expressions of Nε-HEL and acrolein were associated with the pathogenesis of cisplatin-induced nephrotoxicity.