Effect of Compound of Gelatin Hydrogel Microsphere Incorporated with Platelet-Rich-Plasma and Alginate on Sole Defect in Cattle

Nao TSUZUKI; Jong-Pil SEO; Kazutaka YAMADA; Shingo HANEDA; Yasuhiko TABATA; Naoki SASAKI

doi:10.1292/jvms.11-0495

Surgery

Effect of Compound of Gelatin Hydrogel Microsphere Incorporated with Platelet-Rich-Plasma and Alginate on Sole Defect in Cattle

Nao TSUZUKI, Jong-Pil SEO, Kazutaka YAMADA, Shingo HANEDA, Yasuhiko TABATA, Naoki SASAKI

Author information

Nao TSUZUKI
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080–8555, Japan
The United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanado, Gifu 501–1193, Japan
Jong-Pil SEO
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080–8555, Japan
The United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanado, Gifu 501–1193, Japan
Kazutaka YAMADA
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080–8555, Japan
Shingo HANEDA
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080–8555, Japan
Yasuhiko TABATA
Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto 606–8507, Japan
Naoki SASAKI
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080–8555, Japan

Keywords: cattle, drug delivery system, platelet-rich plasma, sole ulcer, tissue engineering

JOURNAL FREE ACCESS

2012 Volume 74 Issue 8 Pages 1041-1044

DOI https://doi.org/10.1292/jvms.11-0495

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Abstract

Platelet-rich plasma (PRP) was administered to cattle with hoof defects (10-mm drill hole) to promote sole defect healing. Two types of gels were prepared. One was a mixed gel [compound of gelatin microspheres (GM) incorporated with PRP and alginate] and was used for the test group, while the other was an alginate gel used for the control group. Each hole was filled with one of these gels. The drill hole depth, pressure pain, and hardness of the regenerated tissue were measured for 3 weeks after treatment. These measurements improved significantly in the test group than in the control group. The results suggest that a compound of GM incorporated with PRP and alginate had a hoof-regenerating effect in cattle.

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