Efficacy of Omeprazole Paste in the Prevention of Gastric Ulcers in 2 Years Old Thoroughbreds

Yoshiro ENDO; Takeru TSUCHIYA; Fumio SATO; Harutaka MURASE; Takaya OMURA; Kenji KOROSUE; Yasuo NAMBO; Mutsuki ISHIMARU; Yasuhiro WAKUI

doi:10.1292/jvms.11-0545

Internal Medicine

Efficacy of Omeprazole Paste in the Prevention of Gastric Ulcers in 2 Years Old Thoroughbreds

Yoshiro ENDO, Takeru TSUCHIYA, Fumio SATO, Harutaka MURASE, Takaya OMURA, Kenji KOROSUE, Yasuo NAMBO, Mutsuki ISHIMARU, Yasuhiro WAKUI

Author information

Yoshiro ENDO
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
Takeru TSUCHIYA
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
Fumio SATO
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
United Graduate School of Veterinary Sciences, Gifu University, Gifu 501–1193, Japan
Harutaka MURASE
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
Takaya OMURA
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
Kenji KOROSUE
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
Yasuo NAMBO
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
United Graduate School of Veterinary Sciences, Gifu University, Gifu 501–1193, Japan
Mutsuki ISHIMARU
Hidaka Training and Research Center, Japan Racing Association, 535–13 Nishicha, Urakawa-cho, Urakawa-gun, Hokkaido 057–0171, Japan
Yasuhiro WAKUI
Merial Japan, Limited, Tokyo Opera City Tower, 3–20–2 Nishi Shinjuku, Shinjuku-ku, Tokyo 163–1488, Japan

Keywords: Equine Gastric Ulcer Syndrome (EGUS), omeprazole, Thoroughbred

JOURNAL FREE ACCESS

2012 Volume 74 Issue 8 Pages 1079-1081

DOI https://doi.org/10.1292/jvms.11-0545

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Abstract

Prevalence of equine gastric ulcer syndrome in 85 young Thoroughbreds was investigated. The presence of gastric ulcers was confirmed in 27.1% (23/85) of the horses by endoscopic examination. Sixty-two horses without gastric ulcers were allocated randomly to either the treated group (31 horses) or sham-dosed control group (31 horses) in order to investigate the efficacy of omeprazole oral paste in the prevention of gastric ulcers. At the second endoscopic examination conducted after 28 days of administration, only 1 horse in the treated group developed gastric ulcers, while 12 horses developed gastric ulcers in the control group. Based on these data, the efficacy of omeprazole in prevention of equine gastric ulcers in young Thoroughbreds during the training period was confirmed.

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