Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related          Activities in Chicken Liver, but Not in Rat Liver

Nobuo SASAKI; Tomoyuki MATUMOTO; Yoshinori IKENAKA; Shouta M. M. NAKAYAMA; Mayumi ISHIZUKA; Akio KAZUSAKA; Shoichi FUJITA

doi:10.1292/jvms.12-0531

Toxicology

Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but Not in Rat Liver

Nobuo SASAKI, Tomoyuki MATUMOTO, Yoshinori IKENAKA, Shouta M. M. NAKAYAMA, Mayumi ISHIZUKA, Akio KAZUSAKA, Shoichi FUJITA

Author information

Nobuo SASAKI
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
Tomoyuki MATUMOTO
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
Yoshinori IKENAKA
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
Shouta M. M. NAKAYAMA
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
Mayumi ISHIZUKA
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
Akio KAZUSAKA
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
Shoichi FUJITA
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan

Keywords: antimicrobial substance, chicken, cytochrome P450, drug metabolism

JOURNAL FREE ACCESS

2013 Volume 75 Issue 11 Pages 1497-1502

DOI https://doi.org/10.1292/jvms.12-0531

Browse “Advance online publication” version

Details

Abstract

The nitrofuran antimicrobial agent, furazolidone (FZ), is still used in veterinary medicine in some countries in the Middle and Far Eastern countries. The present study aimed to investigate the effects of successive bolus doses of FZ and its metabolite 3-amino-2-oxazolidinone (AOZ) on cytochrome P450 (CYP)-related activities in the livers of rats and chickens. Female Wistar rats and white Leghorn chickens were orally administered FZ once a day for 4 consecutive days. FZ-treated chickens showed an increase in multiple CYP-related activities, however, rats treated with FZ did not show these changes. In chickens, treatment with FZ also induced production of microsomal CYP2C6-like apoprotein. The present study demonstrated that FZ caused a multiple-type induction of CYP-related activities in chickens, but not in rats.

Corresponding author

Register with J-STAGE for free!