Combined Hepatocellular-Cholangiocarcinoma in a Yellow-Headed Amazon              (Amazona oratrix)

Anusha Hemamali TENNAKOON; Takeshi IZAWA; Daisuke FUJITA; Yuki DENDA; Eiko SETO; Hiroshi SASAI; Mitsuru KUWAMURA; Jyoji YAMATE

doi:10.1292/jvms.13-0192

Pathology

Combined Hepatocellular-Cholangiocarcinoma in a Yellow-Headed Amazon (Amazona oratrix)

Anusha Hemamali TENNAKOON, Takeshi IZAWA, Daisuke FUJITA, Yuki DENDA, Eiko SETO, Hiroshi SASAI, Mitsuru KUWAMURA, Jyoji YAMATE

Author information

Anusha Hemamali TENNAKOON
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ourai-kita, Izumisano city, Osaka 598–8531, Japan
Takeshi IZAWA
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ourai-kita, Izumisano city, Osaka 598–8531, Japan
Daisuke FUJITA
Kitasuma Animal Hospital, Kobe city, Hyogo 654–0131, Japan
Yuki DENDA
Kitasuma Animal Hospital, Kobe city, Hyogo 654–0131, Japan
Eiko SETO
Kitasuma Animal Hospital, Kobe city, Hyogo 654–0131, Japan
Hiroshi SASAI
Kitasuma Animal Hospital, Kobe city, Hyogo 654–0131, Japan
Mitsuru KUWAMURA
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ourai-kita, Izumisano city, Osaka 598–8531, Japan
Jyoji YAMATE
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-ourai-kita, Izumisano city, Osaka 598–8531, Japan

Keywords: combined hepatocellular-cholangiocarcinoma, immunohistochemistry, liver, Yellow-headed Amazon

JOURNAL FREE ACCESS

2013 Volume 75 Issue 11 Pages 1507-1510

DOI https://doi.org/10.1292/jvms.13-0192

Browse “Advance online publication” version

Details

Abstract

A 9-year-old male Yellow-headed Amazon (Amazona oratrix) with a history of anorexia and vomiting died of a liver tumor. The tumor consisted of neoplastic cells with hepatocellular and cholangiocellular differentiations and their intermingled areas. Neoplastic hepatocytes showed islands or trabecular growth with vacuolated eosinophilic cytoplasm. Cells showing biliary differentiation formed ducts or tubules lined by cytokeratin AE1/AE3-positive epithelia, accompanied by desmoplasia consisting of myofibroblasts reacting to α-smooth muscle actin and desmin. The tumor was diagnosed as a combined hepatocellular-cholangiocarcinoma, which is very rare in the avian.

Corresponding author

Register with J-STAGE for free!