Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Immunology
Foxp3 Expression in Bovine CD8+ T Cells Is Associated with the Intensity of CD25 Expression
Tomasz MASLANKAJerzy Jan JAROSZEWSKI
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Keywords: bovine, CD8, CD25, Foxp3, regulatory
JOURNALS FREE ACCESS

2013 Volume 75 Issue 2 Pages 241-244

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Abstract

The aim of the undertaken research was to determine whether Foxp3+CD25+CD8+ cells exist in cattle and whether Foxp3 expression in CD8+ T cells is correlated with the intensity of CD25 expression. It has been found that 0.66 and 2.36% of CD8+ cells on average showed high and low expression of the CD25 molecule, respectively. On average, 11.61% of CD25highCD8+ cells expressed Foxp3, while the mean percentage of Foxp3+ cells within CD25lowCD8+ cells was 3.66%. The absolute count of Foxp3+CD25highCD8+ cells was not significantly different from the absolute count of Foxp3+CD25lowCD8+ cells. The obtained results indicate that CD8+ cells with the regulatory phenotype, i.e. Foxp3+CD25highCD8+ and Foxp3+CD25lowCD8+ cells, occur naturally in bovine peripheral blood, although both of these subpopulations are relatively small. There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8+ cells.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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