Notch2 Transduction by Feline Leukemia Virus in          a Naturally Infected Cat

Shinya WATANABE; Jumpei ITO; Takuya BABA; Takahiro HIRATSUKA; Kyohei KUSE; Haruyo OCHI; Yukari ANAI; Masaharu HISASUE; Hajime TSUJIMOTO; Kazuo NISHIGAKI

doi:10.1292/jvms.13-0344

Virology

Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat

Shinya WATANABE, Jumpei ITO, Takuya BABA, Takahiro HIRATSUKA, Kyohei KUSE, Haruyo OCHI, Yukari ANAI, Masaharu HISASUE, Hajime TSUJIMOTO, Kazuo NISHIGAKI

著者情報

Shinya WATANABE
Laboratory of Molecular Immunology and Infectious Disease, United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Jumpei ITO
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Takuya BABA
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Takahiro HIRATSUKA
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Kyohei KUSE
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Haruyo OCHI
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Yukari ANAI
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Masaharu HISASUE
Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252–5201, Japan
Hajime TSUJIMOTO
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
Kazuo NISHIGAKI
Laboratory of Molecular Immunology and Infectious Disease, United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

キーワード: feline leukemia virus, hypercalcemia, lymphoma, Notch2, transduction

ジャーナルフリー

2014 年 76 巻 4 号 p. 553-557

DOI https://doi.org/10.1292/jvms.13-0344

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詳細

抄録

Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of a reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.

責任著者(Corresponding author)

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