A new insertion/deletion fragment polymorphism of inhibin-α gene associated          with follicular cysts in Large White sows

Wanhong LI; Shuxiong CHEN; Hongjiao LI; Zhuo LIU; Yun ZHAO; Lu CHEN; Xu ZHOU; Chunjing LI

doi:10.1292/jvms.14-0489

Theriogenology

A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows

Wanhong LI, Shuxiong CHEN, Hongjiao LI, Zhuo LIU, Yun ZHAO, Lu CHEN, Xu ZHOU, Chunjing LI

Author information

Wanhong LI
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China
Shuxiong CHEN
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China
Hongjiao LI
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China
Zhuo LIU
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China
Yun ZHAO
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China
Lu CHEN
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China
Xu ZHOU
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China
Chunjing LI
College of Animal Sciences, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, 5333 Xian Road, Changchun, Jilin 130062, P. R. of China

Keywords: follicular cyst, inhibin α, polymorphism, swine

JOURNAL FREE ACCESS

2016 Volume 78 Issue 3 Pages 473-476

DOI https://doi.org/10.1292/jvms.14-0489

Browse “Advance online publication” version

Details

Abstract

Ovarian follicular cysts are anovulatory follicular structures that lead to infertility. Hormones play key roles in the formation and persistence of cysts. Inhibins are heterodimeric gonadal glycoprotein hormones that belong to the transforming growth factor-β superfamily. These hormones suppress the secretion of follicle-stimulating hormone. In this report, partial fragment of inhibin-α (INHA) subunit gene of Large White pig was detected from the genomic DNA by polymerase chain reaction. The sequence showed a 283 bp fragment insertion/deletion (I/D) polymorphism in INHA subunit gene. A total of 49 Large White sows with cystic follicles and 152 normal sows were screened for this polymorphism. The relationship of INHA I/D polymorphisms with follicular cysts was investigated. The distribution of I/D was significantly different between cystic and normal sows, thereby suggesting that the INHA subunit gene might be a potential biological marker for breeding programs in pig.

Corresponding author

Register with J-STAGE for free!