Coronary artery vasospasms in a microminipig occurred after          placing an ameroid constrictor

Xin CAO; Yuji NAKAMURA; Takayuki AOKI; Takeshi WADA; Hiroko IZUMI-NAKASEKO; Kentaro ANDO; Ryuzo SAKATA; Atsushi SUGIYAMA

doi:10.1292/jvms.16-0005

Laboratory Animal Science

Coronary artery vasospasms in a microminipig occurred after placing an ameroid constrictor

Xin CAO, Yuji NAKAMURA, Takayuki AOKI, Takeshi WADA, Hiroko IZUMI-NAKASEKO, Kentaro ANDO, Ryuzo SAKATA, Atsushi SUGIYAMA

Author information

Xin CAO
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Yuji NAKAMURA
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Takayuki AOKI
Department of Cardiovascular Surgery, Faculty of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606–8501, Japan
Takeshi WADA
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Hiroko IZUMI-NAKASEKO
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Kentaro ANDO
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan
Ryuzo SAKATA
Department of Cardiovascular Surgery, Faculty of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606–8501, Japan
Atsushi SUGIYAMA
Department of Pharmacology, Faculty of Medicine, Toho University, 5–21–16 Omori-nishi, Ota-ku, Tokyo 143–8540, Japan

Keywords: ameroid constrictor, coronary vasospasm, sudden cardiac death

JOURNAL FREE ACCESS

2016 Volume 78 Issue 7 Pages 1213-1216

DOI https://doi.org/10.1292/jvms.16-0005

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Abstract

A 12-month-old microminipig, weighing 12.6 kg, showed 3 repeated episodes of transient ST-segment elevation in 24 hr Holter electrocardiogram after placing an ameroid constrictor around the left anterior descending coronary artery. Ventricular fibrillation was noticed just after the cessation of the 24 hr Holter-electrocardiogram recording. Direct current defibrillations and cardiopulmonary resuscitation were performed; however, they were unsuccessful, leading to the animal’s death. Its heart was excised for macroscopic analysis, which indicated that lumen of the ameroid constrictor was not narrowed and that there was no dissection, embolus or thrombus in the coronary arteries, indirectly suggesting that coronary artery vasospasm may have caused the ischemic attacks. Thus, microminipig may possess some potential to have coronary vasospasm.

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