Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Xiaotian NIU; Thobela Louis TYASI; Ning QIN; Dehui LIU; Hongyan ZHU; Xiaoxia CHEN; Fengwei ZHANG; Shuguo YUAN; Rifu XU

doi:10.1292/jvms.17-0014

Laboratory Animal Science

Sequence variations in estrogen receptor 1 and 2 genes and their association with egg production traits in Chinese Dagu chickens

Xiaotian NIU, Thobela Louis TYASI, Ning QIN, Dehui LIU, Hongyan ZHU, Xiaoxia CHEN, Fengwei ZHANG, Shuguo YUAN, Rifu XU

著者情報

Xiaotian NIU
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China
Thobela Louis TYASI
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China
Ning QIN
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China
Dehui LIU
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China
Hongyan ZHU
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China
Xiaoxia CHEN
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China
Fengwei ZHANG
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China
Shuguo YUAN
Jilin Grain Group Agriculture and Livestock Co., Ltd., Changchun 130062, Jilin, China
Rifu XU
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China

キーワード: Dagu hens, egg production trait, estrogen receptors α, estrogen receptors β, polymorphisms

ジャーナルフリー

2017 年 79 巻 5 号 p. 927-934

DOI https://doi.org/10.1292/jvms.17-0014

Browse “Advance online publication” version

詳細

抄録

Estrogen receptors α (ESR1) and β (ESR2) play central roles in folliculogenesis and therefore in reproductive biology. In the present study, two single nucleotide polymorphisms (SNPs) were identified in the ESR1 and ESR2 genes using PCR-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing. One of the identified SNPs, a T1101C transition located within exon 4 of the ESR1 gene, was significantly associated with hen-housed egg production (HHEP) at 30, 43, 57 and 66 weeks of age (P<0.05), and egg weight (EW) at 30 weeks (P<0.05). Another SNP, a G1755A transition leading to a non-synonymous substitution (valine 459-to-isoleucine) located within exon 8 of the ESR2 gene, was also markedly correlated with the HHEP at 30, 43, 57 and 66 weeks of age (P<0.05), and EW at 30 weeks (P<0.05). A greater proportion of the additive variance was explained by the SNPs for most of the associated egg production traits (>1%). Furthermore, the results of the combined genotype-based association analysis supported the finding that the two SNPs were associated with the traits under a study. Taken together, our findings suggest that the two sequence variations in the ESR1 and ESR2 genes may provide promising genetic markers for the early selection and prediction of advantageous phenotypes in chicken breeding.

責任著者(Corresponding author)

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