Spontaneous regression of canine papillomavirus type 2-related papillomatosis          on footpads in a dog

Keita IYORI; Kiyohiko INAI; Hidekatsu SHIMAKURA; Takeshi HAGA; Hiromi SHIMOURA; Ichiro IMANISHI; Akihiro IMAI; Toshiro IWASAKI

doi:10.1292/jvms.19-0136

Internal Medicine

Spontaneous regression of canine papillomavirus type 2-related papillomatosis on footpads in a dog

Keita IYORI, Kiyohiko INAI, Hidekatsu SHIMAKURA, Takeshi HAGA, Hiromi SHIMOURA, Ichiro IMANISHI, Akihiro IMAI, Toshiro IWASAKI

Author information

Keita IYORI
Vet Derm Tokyo, Laboratory and Clinical Dermatology Services, 2-24-3, Kameido, Koto-ku, Tokyo 136-0071, Japan
Kiyohiko INAI
Vet Derm Osaka, 2-3-55 Senbahigashi, Minoh, Osaka 562-0035, Japan
Hidekatsu SHIMAKURA
Division of Infection Control and Disease Prevention, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Takeshi HAGA
Division of Infection Control and Disease Prevention, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Hiromi SHIMOURA
Vet Derm Tokyo, Laboratory and Clinical Dermatology Services, 2-24-3, Kameido, Koto-ku, Tokyo 136-0071, Japan
Vet Derm Osaka, 2-3-55 Senbahigashi, Minoh, Osaka 562-0035, Japan
Ichiro IMANISHI
Laboratory of Veterinary Internal Medicine, Division of Animal Life Science, Graduate School, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
Akihiro IMAI
Dermatology Service, Synergy Animal General Hospital, 815 Ishigami, Kawaguchi, Saitama 333-0823, Japan
Toshiro IWASAKI
Vet Derm Osaka, 2-3-55 Senbahigashi, Minoh, Osaka 562-0035, Japan

Keywords: canine papillomavirus type 2, footpad papillomatosis, spontaneous regression

JOURNAL FREE ACCESS
Supplementary material

2019 Volume 81 Issue 6 Pages 933-936

DOI https://doi.org/10.1292/jvms.19-0136

Browse “Advance online publication” version

Details

Abstract

Persistent papillomatosis on footpads related to canine papillomavirus type 2 (CPV-2) infection has been described in dogs with immunocompromised condition. A 9-year-old, male French bulldog was presented with cauliflower-like nodules on the footpads of his left front leg. Histopathological examination revealed multiple finger-like projections of squamous epithelium with intranuclear inclusion bodies. Immunohistochemistry using an anti-bovine papillomavirus antibody demonstrated immunostaining in the keratinocytes. Partial genome DNA of CPV-2 was amplified from the lesion. Full genome sequence of CPV-2 in the subject showed 99.95% nucleotide identity with that of CPV-2 from the reference data. Two weeks after a biopsy, the skin lesion spontaneously regressed without any specific treatment. In non-immunocompromised dogs, CPV-2-related footpad papillomatosis could spontaneously resolve after a biopsy.

Corresponding author

Register with J-STAGE for free!