Gene expression of leucine-rich alpha-2 glycoprotein in the polypoid lesion          of inflammatory colorectal polyps in miniature dachshunds

Hiroshi OHTA; Yu TAMURA; Nozomu YOKOYAMA; Noriyuki NAGATA; Tatsuyuki OSUGA; Noboru SASAKI; Yumiko KAGAWA; Keitaro MORISHITA; Mitsuyoshi TAKIGUCHI

doi:10.1292/jvms.20-0242

Internal medicine

Gene expression of leucine-rich alpha-2 glycoprotein in the polypoid lesion of inflammatory colorectal polyps in miniature dachshunds

Hiroshi OHTA, Yu TAMURA, Nozomu YOKOYAMA, Noriyuki NAGATA, Tatsuyuki OSUGA, Noboru SASAKI, Yumiko KAGAWA, Keitaro MORISHITA, Mitsuyoshi TAKIGUCHI

著者情報

Hiroshi OHTA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Yu TAMURA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Present address: Veterinary Teaching Hospital, Azabu University, Kanagawa 252-5201, Japan
Nozomu YOKOYAMA
Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Noriyuki NAGATA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Tatsuyuki OSUGA
Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Noboru SASAKI
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Yumiko KAGAWA
NORTH LAB, Hondori 2-chome, kita8-35, Shiroishi-ku, Sapporo, Hokkaido 003-0027, Japan
Keitaro MORISHITA
Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Mitsuyoshi TAKIGUCHI
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan

キーワード: inflammatory colorectal polyp, inflammatory cytokine, leucine-rich alpha-2 glycoprotein, miniature dachshund

ジャーナルオープンアクセス

2020 年 82 巻 10 号 p. 1445-1449

DOI https://doi.org/10.1292/jvms.20-0242

Browse “Advance online publication” version

詳細

抄録

Inflammatory colorectal polyps (ICRPs) in miniature dachshunds (MDs) are speculated to be a breed-specific inflammatory bowel disease (IBD). Leucine-rich alpha-2 glycoprotein (LRG) has been identified as a novel biomarker of human IBD. The aim of this study was to examine LRG gene expression in the polypoid lesions of ICRPs. Polypoid lesion specimens were collected from 24 MDs with ICRPs. Nonpolypoid colonic mucosa was collected from 18 MDs with ICRPs and 10 controls. The gene expression of LRG, interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and IL-22 was examined. The expression of LRG gene was significantly increased in the polypoid lesions of ICRPs and correlated with that of the four cytokines. In conclusion, the LRG gene was expressed within the polypoid lesions of ICRPs and might be associated with local cytokine expression.

責任著者(Corresponding author)

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