Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)

Kraisiri KHIDKHAN; Hazuki MIZUKAWA; Yoshinori IKENAKA; Shouta M. M. NAKAYAMA; Kei NOMIYAMA; Nozomu YOKOYAMA; Osamu ICHII; Mitsuyoshi TAKIGUCHI; Shinsuke TANABE; Mayumi ISHIZUKA

doi:10.1292/jvms.20-0140

Toxicology

Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)

Kraisiri KHIDKHAN, Hazuki MIZUKAWA, Yoshinori IKENAKA, Shouta M. M. NAKAYAMA, Kei NOMIYAMA, Nozomu YOKOYAMA, Osamu ICHII, Mitsuyoshi TAKIGUCHI, Shinsuke TANABE, Mayumi ISHIZUKA

Author information

Kraisiri KHIDKHAN
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Hazuki MIZUKAWA
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Department of Science and Technology for Biological Resources and Environment, Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan
Yoshinori IKENAKA
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom 2531, South Africa
Shouta M. M. NAKAYAMA
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Kei NOMIYAMA
Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan
Nozomu YOKOYAMA
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Osamu ICHII
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Laboratory of Agrobiomedical Science, Faculty of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo, Hokkaido 060-8589, Japan
Mitsuyoshi TAKIGUCHI
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan
Shinsuke TANABE
Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan
Mayumi ISHIZUKA
Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan

Keywords: BDE-209, cat, chronic exposure, cytochrome P450, mRNA expression

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Supplementary material

2020 Volume 82 Issue 7 Pages 978-982

DOI https://doi.org/10.1292/jvms.20-0140

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Abstract

The knowledge of cytochrome P450 (CYP) expression involved in chemical exposure are necessary in clinical applications for the medication and prediction of adverse effects. The aim of this study was to evaluate the mRNA expression of CYP1–CYP3 families in cats exposed to BDE-209 for one year. All selected CYP isoforms showed no significant difference in mRNA expressions between control and exposure groups, however, CYP3A12 and CYP3A131 revealed tend to be two times higher in the exposure group compared to control group. The present results indicate that the chronic exposure of BDE209 could not alter CYP expression in the liver of cats. This result considered caused by the deficiency of CYP2B subfamily which is major metabolism enzyme of polybrominated diphenyl ethers (PBDEs) in cat.

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