Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Pathology
Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
Akira YABUKIYu FURUSAWANoriaki MIYOSHIKazuyuki TANIGUCHIOsamu YAMATO
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JOURNAL OPEN ACCESS

2021 Volume 83 Issue 5 Pages 837-840

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Abstract

Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal nitric oxide synthase in the dysplastic kidneys of three young dogs. Renin-immunoreactivity, which occurs in the juxtaglomerular and tubular cells of dysplastic kidneys, did not differ from that in the normal kidneys of young dogs. Macula densa cells in the normal kidneys showed neuronal nitric oxide synthase -immunoreactivity, but those in the dysplastic kidneys showed no apparent signals. This observation may be correlated with the pathological mechanisms of renal failure in young dogs.

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© 2021 by the Japanese Society of Veterinary Science

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