Comparison of prevalence of Felis catus papillomavirus type 2 in squamous cell carcinomas in cats between Taiwan and Japan

Nanako YAMASHITA-KAWANISHI; Chia Yu CHANG; James K CHAMBERS; Kazuyuki UCHIDA; Katsuaki SUGIURA; Iwao KUKIMOTO; Hui Wen CHANG; Takeshi HAGA

doi:10.1292/jvms.21-0153

Virology

Comparison of prevalence of Felis catus papillomavirus type 2 in squamous cell carcinomas in cats between Taiwan and Japan

Nanako YAMASHITA-KAWANISHI, Chia Yu CHANG, James K CHAMBERS, Kazuyuki UCHIDA, Katsuaki SUGIURA, Iwao KUKIMOTO, Hui Wen CHANG, Takeshi HAGA

Author information

Nanako YAMASHITA-KAWANISHI
Division of Infection Control and Disease Prevention, Department of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Chia Yu CHANG
Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan
James K CHAMBERS
Laboratory of Veterinary Pathology, Department of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Kazuyuki UCHIDA
Laboratory of Veterinary Pathology, Department of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Katsuaki SUGIURA
Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Iwao KUKIMOTO
Pathogen Genomics Center, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-murayama, Tokyo 162-0052, Japan
Hui Wen CHANG
Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan
Takeshi HAGA
Division of Infection Control and Disease Prevention, Department of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan

Keywords: Felis catus papillomavirus type 2, Japan, molecular epidemiology, squamous cell carcinoma, Taiwan

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Supplementary material

2021 Volume 83 Issue 8 Pages 1229-1233

DOI https://doi.org/10.1292/jvms.21-0153

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Abstract

Felis catus papillomavirus (FcaPV), especially type 2 (FcaPV2) is considered as one of the causative agents in squamous cell carcinoma (SCC) in cats. However, our previous study detected FcaPV3 and FcaPV4, but not FcaPV2 in feline SCCs collected in Japan, suggesting that the prevalence of FcaPV2 in SCC may vary depending on geographic locations. To evaluate this hypothesis, two conventional PCR reactions targeting E1 and E7 genes were performed to detect FcaPV2 in feline SCC samples collected in Taiwan and Japan. While 46.9% (23/49) of feline SCC cases from Taiwan were PCR positive for FcaPV2, only 8.6% (3/35) cases from Japan were positive. Our result suggests that the prevalence of FcaPV2 in feline SCCs may depend on the region.

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