論文ID: 09-0050
In this study, cDNA of Toll-like receptor (TLR) 3, 7, and 9 were synthesized and completely sequenced. The coding regions of cDNA for bat TLR3, 7, and 9 were 2,718, 3,150, and 3,090 bp in length, respectively. Open reading frames encoded 905, 1,049, and 1,029 amino acids for TLR3, 7, and 9, respectively. Nucleotide sequences, predicted amino acid sequences and predicted domain structures of the three bat TLRs had high homology with those of other mammals. In addition, the expression profile of each TLR in main organs was analyzed. Expression of TLR3 was highest in liver, whereas TLR7 and TLR9 expression was highest in spleen.