Early Mortality Following Intracerebral Infection with Tick-Borne Encephalitis Virus Oshima Strain in a Mouse Model

Abstract

Tick-borne encephalitis virus (TBEV) is a zoonotic agent which causes acute central nervous system (CNS) disease in humans. In this study, we examined the pathogenic process following intracerebral infection with TBEV Oshima strain in a mouse model. Intracerebral infection resulted in dose-dependent mortality, and all mice died following challenge with 10² PFU or more of virus within 10 days. Acutely necrotic neurons and widespread inflammation were observed throughout the CNS. We therefore conclude that mortality following intracerebral infection results from a direct CNS pathology.